A herbal formula for prevention of influenza-like syndrome: A double-blind randomized clinical trial
Identifieur interne : 001463 ( Main/Exploration ); précédent : 001462; suivant : 001464A herbal formula for prevention of influenza-like syndrome: A double-blind randomized clinical trial
Auteurs : Lai-Yi Wong [République populaire de Chine] ; Ping-Chung Leung [République populaire de Chine, Hong Kong] ; Suet-Yee Pang [République populaire de Chine] ; King-Fai Cheng [République populaire de Chine] ; Chun-Kwok Wong [République populaire de Chine] ; Wai-Kei Lam [République populaire de Chine] ; Kwok-Pui Fung [République populaire de Chine] ; Tak-Fai Lau [République populaire de Chine] ; Yee-Kit Tse [République populaire de Chine] ; Chi-Yui Kwok [République populaire de Chine]Source :
- Chinese Journal of Integrative Medicine [ 1672-0415 ] ; 2013-04-01.
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Abstract
Abstract: Objective: To investigate the efficacy of a herbal formula in the prevention of influenza or influenza-like syndrome among elderies residing in old-people’s home in Hong Kong. The secondary objectives are to investigate the quality of life (QOL) and symptomology changes among the herbal users and to evaluate the safety of this formula. Methods: In ten old people’s home or community centres in New Territories, Hong Kong, 740 eligible subjects agreed to join the study and were randomized to receive a herbal formula or a placebo on alternate days over 8 weeks. Among those 740 participants, 113 had provided blood samples for immunological assessments before and after the study drug. Assessments were done at 0, 4, 8 and 12 weeks. Participants were instructed to keep a daily record of body temperature and any symptoms as sore throat, myalgia, running nose or cough, and to report to assessor accordingly. Those reporting body temperature of 37.8 °C and above would be visited and a proper nasopharyngeal swab be taken for viral study. Results: Seventy-two participants developed influenza-like-symptoms but none of them was proven influenza in their nasopharyngeal swabs, 40 of these patients belonged to the herbal group and 32 to the placebo group, without significant differences between groups. The difference on the changes in QOL between the two groups was not statistically significant. However, in the immunological study, the natural killer cell absolute count was significantly increased in the herbal group compared with the placebo group (463±253 vs 413±198, P<0.05). Conclusions: The herbal preparation was not effective compared with placebo in the prevention of influenza-like syndrome. It was however safe and possibly supporting immunological responses.
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DOI: 10.1007/s11655-012-1269-6
Affiliations:
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J. Integr. Med.</title><idno type="ISSN">1672-0415</idno><idno type="eISSN">1993-0402</idno><imprint><publisher>Chinese Association of Traditional and Western Medicine</publisher><pubPlace>Heidelberg</pubPlace><date type="published" when="2013-04-01">2013-04-01</date><biblScope unit="volume">19</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="253">253</biblScope><biblScope unit="page" to="259">259</biblScope></imprint><idno type="ISSN">1672-0415</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1672-0415</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>complementary medicine</term><term>herbal treatment</term><term>influenza</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objective: To investigate the efficacy of a herbal formula in the prevention of influenza or influenza-like syndrome among elderies residing in old-people’s home in Hong Kong. The secondary objectives are to investigate the quality of life (QOL) and symptomology changes among the herbal users and to evaluate the safety of this formula. Methods: In ten old people’s home or community centres in New Territories, Hong Kong, 740 eligible subjects agreed to join the study and were randomized to receive a herbal formula or a placebo on alternate days over 8 weeks. Among those 740 participants, 113 had provided blood samples for immunological assessments before and after the study drug. Assessments were done at 0, 4, 8 and 12 weeks. Participants were instructed to keep a daily record of body temperature and any symptoms as sore throat, myalgia, running nose or cough, and to report to assessor accordingly. Those reporting body temperature of 37.8 °C and above would be visited and a proper nasopharyngeal swab be taken for viral study. Results: Seventy-two participants developed influenza-like-symptoms but none of them was proven influenza in their nasopharyngeal swabs, 40 of these patients belonged to the herbal group and 32 to the placebo group, without significant differences between groups. The difference on the changes in QOL between the two groups was not statistically significant. However, in the immunological study, the natural killer cell absolute count was significantly increased in the herbal group compared with the placebo group (463±253 vs 413±198, P<0.05). Conclusions: The herbal preparation was not effective compared with placebo in the prevention of influenza-like syndrome. It was however safe and possibly supporting immunological responses.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wong, Lai Yi" sort="Wong, Lai Yi" uniqKey="Wong L" first="Lai-Yi" last="Wong">Lai-Yi Wong</name></noRegion><name sortKey="Cheng, King Fai" sort="Cheng, King Fai" uniqKey="Cheng K" first="King-Fai" last="Cheng">King-Fai Cheng</name><name sortKey="Fung, Kwok Pui" sort="Fung, Kwok Pui" uniqKey="Fung K" first="Kwok-Pui" last="Fung">Kwok-Pui Fung</name><name sortKey="Kwok, Chi Yui" sort="Kwok, Chi Yui" uniqKey="Kwok C" first="Chi-Yui" last="Kwok">Chi-Yui Kwok</name><name sortKey="Lam, Wai Kei" sort="Lam, Wai Kei" uniqKey="Lam W" first="Wai-Kei" last="Lam">Wai-Kei Lam</name><name sortKey="Lau, Tak Fai" sort="Lau, Tak Fai" uniqKey="Lau T" first="Tak-Fai" last="Lau">Tak-Fai Lau</name><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name><name sortKey="Pang, Suet Yee" sort="Pang, Suet Yee" uniqKey="Pang S" first="Suet-Yee" last="Pang">Suet-Yee Pang</name><name sortKey="Tse, Yee Kit" sort="Tse, Yee Kit" uniqKey="Tse Y" first="Yee-Kit" last="Tse">Yee-Kit Tse</name><name sortKey="Wong, Chun Kwok" sort="Wong, Chun Kwok" uniqKey="Wong C" first="Chun-Kwok" last="Wong">Chun-Kwok Wong</name></country><country name="Hong Kong"><noRegion><name sortKey="Leung, Ping Chung" sort="Leung, Ping Chung" uniqKey="Leung P" first="Ping-Chung" last="Leung">Ping-Chung Leung</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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